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Anti-thyroid drugs are used to treat hyperthyroidism (overactive thyroid) also known as “thyrotoxicosis”. There are medications available to immediately treat the symptoms of hyperthyroidism, such as a rapid heart rate. One of the main classes of drugs used to treat these symptoms is the beta-blockers. Beta-blockers should be given to most hyperthyroid patients who do not have a contraindication to their use. Anti-thyroid drugs are most often used as the primary treatment for persons with Graves’ disease. In patients with Graves’ disease, beta-blockers are typically co-administered with a thionamide, but they can be given alone in patients treated with radio-iodine. Anti-thyroid drugs decrease the levels of the two hormones produced by the thyroid, thyroxine (T4) and triiodothyronine (T3). Once a patient has been started on an anti-thyroid drug, follow-up testing of thyroid function every four to six weeks is recommended, at least until thyroid function is stable. Most of the side effects of antithyroid drugs are minor, but major side effects can also occur. You should discuss with your doctor about benefits versus side effects.